The left upper lobe resection specimens:1. (left upper lobe)Central type malignant tumor. According to the histological and immunophenotypic features, solid adenocarcinoma was considered, with pleural invasion; 2. No cancer tissue was found in bronchial stump; 3. (chest nodule) no cancer tissue was found; 4.Metastatic carcinoma was found in (Group 5) lymph node (1 / 3). No metastatic carcinoma was found inanother (Group 11) lymph node (0 / 1), (left laryngeal reflux) ）lymph node (0 / 2), (Group 7)lymph node, (0 / 8), (Group 9) lymph node (0 / 1) and (Group 11) lymph node (0 / 5).
CK18(+),EMA(++),TTF-1(+),NapsinA(+,a few cells),CK5/6(+,A few cells),Vimentin(+),Ki-67(+,about30%),CK7(+,A few cells),SP-B(-),P63(-),P40(-),Syn(-),CgA(-),CD56(-) CD117(-).
The left upper lobectomy specimen: The volume is 14 * 10 * 3.5cm. There were a grayish yellow mass with partial defect can be seen 0.8cm away from the bronchial stump. The remaining volume is 6 * 5.5 * 4cm. The section is grayish yellow and medium in quality. In addition, four chest nodules with a diameter of 1-2cm are sentfor examination, which is cystic locally.
Gender：F
Age：44
family history ：Parents are alive
Serological examination ：Serum CEA was slightly higher and NSE was normal
surgical mode ：left upper lobectomy
Tumor size： 6 * 5.5 * 4cm four chest nodules with
Disease status(primary/relapse)：primary
G：III
TNM：T3N1M0
Stage：IIIA
Gene：ROS1
Mutant Site：PCR
Mutation Type：fusion
% tumor ：*
% necrosis：*
